Reference of 345637-71-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 2-(5-methyl-3-(trifluoromethyl)-l H-pyrazol- l -yl)acetic acid ( 129 mg, 0.6 mmol) in N, N-dimethyformamide ( 5 mL), l -[bis(dimethylamino)methylene]- l H-l ,2,3-triazolo[4,5-b]pyridinium 3- oxid hexafluorophosphate (HATU) (258 mg, 0.7 mmol) and N, N-diisopropylethylamine (0.6 mL, 3.4 mmol) was added. The resulting clear solution was stirred for 10 min at 25 C. N-((2,6- difluorophenyl)(methyl)(o o)-lambda6-sulfanylidene)-2-(piperidin-4-yl)thiazole-4-cai·boxamide (21 8 mg, 0.6 mmol) was added and the resulting yellow solution was stirred for 16 h at 25 C. After completion of the reaction, the reaction mixture was quenched with a brine solution ( 1 50 mL). The reaction mixture was extracted twice with ethyl acetate (50 mL). The ethyl acetate layer was concentrated and the residue was purified using column chromatography using 80% ethyl acetate in hexane as an eluent to obtain N-((2,6- difluorophenyl)(methyl)(oxo)-6-sulfanylidene)-2-( l -(2-(5-methyl-3-(trifluoromethyl)- l H^yl)acetyl)piperidin-4-yl)thiazole-4-carboxamide (26 mg, 0.05 mmol, 8% yield).-NMR (400 MHz, DMSO-d6) delta 8.28 (s, 1 H), 7.80-7.87 (m, 1 H), 7.38 (t, J = 9.0 Hz, 2H), 7.1 8 (t, J = 53.3 Hz, 1 H), 7.04 (t, J = 54.2 Hz, 1 H), 6.92-7.22 (m, 1 H), 5.40 (dd, J = 33.2, 16.6 Hz, 2H), 4.35 (d, J = 13.0 Hz, 1 H), 3.97 (d, J = 13.0 Hz, 1 H), 3.72 (s, 3H), 3.25 (t, J = 1 1 .9 Hz, 1 H), 2.79-2.85 (m, 1 H), 2.08 (s,3H), 1 .78 (dd, J = 28.0, 1 5.0 Hz, 1 H), 1 .50- 1 .59 (m, 1 H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PI INDUSTRIES LTD.; SHANBHAG, Gajanan; SHARMA, Aditya; RENUGADEVI, G.; PABBA, Jagadish; DENGALE, Rohit Arvind; ROY, Dipankar; S.P., Mohan Kumar; BELKAR, Yogesh Kashiram; AUTKAR, Santosh Shridhar; GARG, Ruchi; VENKATESHA, Hagalavadi M; KLAUSENER, Alexander Guenther Maria; (114 pag.)WO2019/48988; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics