Reference of 1105039-93-7, These common heterocyclic compound, 1105039-93-7, name is 1-(4-Methoxybenzyl)-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 1-(4-methoxy-benzyl)-1H-pyrazole-4-carboxylic acid (0.45 g, 1.94 mmol), oxalyl chloride (1.2 ml) and DMF (1 drop) was heated at 60 C. for 1 h. The mixture was allowed to cool to ambient temperature and evaporated to afford the title compound as a colourless oil (0.48 g, 99%). The material was used in the next step without further purification.
Statistics shows that 1-(4-Methoxybenzyl)-1H-pyrazole-4-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 1105039-93-7.
Reference:
Patent; Genentech, Inc.; Dyke, Hazel Joan; Gancia, Emanuela; Gazzard, Lewis J.; Goodacre, Simon Charles; Lyssikatos, Joseph P.; MacLeod, Calum; Williams, Karen; Chen, Huifen; US2015/368244; (2015); A1;,
Pyrazole – Wikipedia,
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