Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34605-66-8, name is 3-(2,5-Dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Computed Properties of C10H13N3
Step 2) 2-(3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazol-5-yl)propan-2-ol At -78 C., to a solution of 3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole (708.5 mg, 4.04 mmol) in THF (8 mL) was added n-BuLi (2.4 M in THF, 2.5 mL, 6.00 mmol) dropwise. The reaction mixture was continued to stir at -78 C. for 0.5 h and then move to 0 C. for 2 h. Acetone (362.1 mg, 6.24 mmol) was added to the solution. The reaction mixture was stirred at rt for 3 h, quenched with water (20 mL), and extracted with EtOAc (50 mL*3). The combined organic phases were washed with brine (50 mL), dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v)=1/5) to give the title compound as yellow oil (353.0 mg, yield 37.4%). LC-MS (ESI, pos. ion) m/z: 234.4 [M+H]+; 1H NMR (400 MHz, CDCl3): delta (ppm) 5.99 (s, 1H), 5.85 (s, 2H), 4.10 (s, 3H), 2.12 (s, 6H), 1.88 (br. s, 1H), 1.70 (s, 6H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Sunshine Lake Pharma Co., Ltd.; Calitor Sciences, LLC; Xi, Ning; Li, Minxiong; Li, Xiaobo; Dai, Weilong; Hu, Haiyang; Zhang, Tao; Chen, Wuhong; (78 pag.)US2016/229837; (2016); A1;,
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