Related Products of 398495-65-3,Some common heterocyclic compound, 398495-65-3, name is 5-tert-Butyl 1-ethyl 3-aminopyrrolo[3,4-c]pyrazole-1,5(4H,6H)-dicarboxylate, molecular formula is C13H20N4O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 3-amino-5-tert-butyloxycarbonyl-1-ethoxycarbonyl- -4, 6- dihydropyrrolo [3,4-c] pyrazole (0.4g, 1.35 mmol) in dry tetrahydrofurane [(10ML)] was added drop wise to a solution of isoamylnitrite (0. [32ML,] 2. [36MMOL)] in dry tetrahydrofurane (2ml) maintained at reflux. The resulting solution was stirred at reflux for 4 hours, and then cooled to room temperature. After removal of the solvent under vacuum, the crude material was purified by flash chromatography on silica gel using n- [HEXANE. ETHYL] acetate [90No.10 ]; 70-30. The title compound was obtained as a light yellow oil (200mg, y 53%). [H-NMR] (DMSO-d6) [8] ppm: 7.67 (s, 1H); 4.54 (m, 2H); 4.39 (q, 2H); 4.32 (m, [2H)] ; 1.43 (s, 9H); 1.31 (t, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-tert-Butyl 1-ethyl 3-aminopyrrolo[3,4-c]pyrazole-1,5(4H,6H)-dicarboxylate, its application will become more common.
Reference:
Patent; PHARMACIA ITALIA SPA; WO2004/13144; (2004); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics