5334-43-0, name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile
General procedure: (General method). Amixture of the appropriate aminonitrile 1 (3.0 mmol) and1,3-dicarbonyl compound (3.0 mmol) in anhydrous toluene(12 ml) was refluxed for 1 h in a flask equipped with aDean-Stark trap. Tin(IV) chloride (3.0 g, 11.5 mmol) wasadded to the reaction mixture, and refluxing was continuedfor additional 5-6 h. A resinous precipitate was formed,andthe colorless toluene layer was decanted. The residualsolvent was removed on a rotary evaporator, the obtainedglassy solids were dissolved in boiling dioxane, cooled, thenpoured into a solution of Na23 (4.0 g) in water (70 ml).The precipitate that formed was filtered off, washed withwater, dried, and recrystallized from a 5:1 mixture of2-PrOH-DMF.
The synthetic route of 5334-43-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Potapov, Andrei Yu.; Vandyshev, Dmitriy Yu.; Kosheleva, Yevgeniya A.; Polikarchuk, Vladimir A.; Potapov, Mikhail A.; Shikhaliev, Khidmet S.; Chemistry of Heterocyclic Compounds; vol. 53; 2; (2017); p. 207 – 212; Khim. Geterotsikl. Soedin.; vol. 53; 2; (2017); p. 207 – 212,6;,
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