Electric Literature of 17635-45-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17635-45-9, name is 4-Pyrazol-1-yl-phenylamine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a stirred suspension of thioacid (1.0 mmol) in THF (5 mL) were added I2 (0.6 mmol, 152 mg), DIPEA (1.2 mmol, 0.156 mL) and HOBt (2.0 mmol, 270 mg) at r.t., followed by the appropriate amine(1.1 mmol). The reaction mixture was stirred for 0.5 to 1 h as analyzed by TLC (until complete disappearance of the thioacid was observed). After the reaction was complete, the solvent was evaporated under vacuum and diluted with EtOAc (20 mL). The organic phase was washed with 10percent HCl (2 × 10 mL), 1 N Na2CO3(3 × 10 mL), H2O (2 × 10 mL) and brine (10 mL) and then dried over anhydrous Na2SO4. The solvent was filtered and evaporated under reduced pressure. The crude reaction mixture was purified under column chromatography using hexane?EtOAc (7:3) as the eluentto afford the desired product.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Pyrazol-1-yl-phenylamine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Madhu, Chilakapati; Vishwanatha; Sureshbabu, Vommina V.; Synthesis; vol. 45; 19; (2013); p. 2727 – 2736;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics