Related Products of 83-10-3, The chemical industry reduces the impact on the environment during synthesis 83-10-3, name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, I believe this compound will play a more active role in future production and life.
Take raw material 1 (0.01mol) and raw material p-aminophenol 2 (0.01mol) was dissolved in DMF 15mL, was addedEDC.HCl (5.75 g, 0.03 mmol) was added and the reaction stirred at room temperature for 8 h. After the reaction was completed, water was added to the reaction solution to precipitate a white solid After stirring for 15 min, the filter cake was washed with water to neutrality and dried in vacuo to give a white solid. Intermediate 3 was obtained in 94% yield.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Huang Daowei; Wang Wenya; Zhang Zhiguo; Jiang Ling; (45 pag.)CN107286140; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics