Adding a certain compound to certain chemical reactions, such as: 27006-76-4, name is 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27006-76-4, name: 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxaldehyde
General procedure: To a solution of substituted phenol (26 mmol) in absolute ethanol (50 mL) was added sodium hydroxide (26 mmol) at room temperature. The mixture was heated to reflux for 3-5 h. After the removal of the solvent, the residue was dissolved in dimethylsulfoxide (50 mL), to the resulting mixture was added 5-chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde (5) (20 mmol) in portions. Then the solution was heated to 105 C and maintained at that temperature for 4-15 h and cooled to room temperature. The reaction mixture was poured into water (100 mL) and extracted with ethyl acetate (3 50 mL). The organic layer was washed with water (3 25 mL) and dried over anhydrous Na2SO4, filtered and evaporated to produce the corresponding carbaldehydes 6d-6w, with yields ranging from 60% to 81% [11].
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Reference:
Article; Dai, Hong; Chen, Jia; Li, Hong; Dai, Baojiang; He, Haibing; Fang, Yuan; Shi, Yujun; Molecules; vol. 21; 3; (2016);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics