Adding a certain compound to certain chemical reactions, such as: 25016-11-9, name is 1-Methyl-1H-pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25016-11-9, Product Details of 25016-11-9
To a 22 L 3-neck RB flask in an ambient temperature water bath was charged with 7-nitro-2,3,4,5-tetrahydro-1H-benzo[d]azepine monosulfate 6 (400 g, 1.38 mol) and sodium acetate (237 g, 2.89 mol) as solids, followed by 5 L MeOH. 1-methyl-1H-pyrazole-4-carbaldehyde (176 g, 1.60 mol) was then added in a single portion. The mixture was stirred for ~1 h, before the addition of sodium cyanoborohydride (143 g, 2.27 mol) in three portions over 15 min. After 2 h, additional sodium cyanoborohydride (13 g) was added, and it was stirred for another 4 h. Sarcosine (19 g, 0.21 mol) was then added and it was stirred at rt overnight. The solution was cooled to ~10 C, before the addition of 8 L water over 0.5 h while cooling in an ice bath. Then 2.5 L of 2N NaOH solution was added over 2.5 h (pH > 12). Additional 1.5 L water was added in a single portion. It was cooled in an ice bath and stirred overnight. The precipitate was collected by filtration, washed with water (2 x 1 L), and dried in vacuum at 50-60 C to afford the title compound (381.7 g, 97%). 1H NMR (500 MHz, d6-DMSO) d ppm 2.49-2.53 (m, 4H), 2.96-2.99 (m, 4H), 3.28 (s, 2H), 3.78 (s, 3H), 7.28 (s, 1H), 7.38 (d, J = 8.0 Hz, 1H), 7.54 (s, 1H), 7.95-7.80 (m, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazole-4-carbaldehyde, and friends who are interested can also refer to it.
Reference:
Article; Xiong, Hui; Wu, Ye; Lehr, Scott G.; Blackwell, William; Steelman, Gary; Hulsizer, Jim; Urbanek, Rebecca A.; Tetrahedron Letters; vol. 53; 44; (2012); p. 5833 – 5836,4;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics