Adding a certain compound to certain chemical reactions, such as: 16461-94-2, name is 4-Bromo-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16461-94-2, Quality Control of 4-Bromo-1H-pyrazol-3-amine
Step 2 :4-(3-Bromopyrazolori,5-a1pyrimidin-6-yl)phenol; A mixture of 3-(dimethylamino)-2-(4-hydroxyphenyl)acrylaldehyde (5.00 g, 0.026 mol), 3-amino-4- bromopyrazole (4.23 g, 0.026 mol), 84 mL of ethanol and 4.2 mL of acetic acid was refluxed for 12 h. The mixture was cooled and the precipitate filtered off, washed twice with water and a small amount of ethanol, then dried in vacuum at 40-500C for 8 h. to give the desired phenol. Yield: 4.66 g (61.5%).
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Reference:
Patent; MERCK SHARP & DOHME LIMITED; MERCK & CO., INC.; WO2007/85873; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics