Reference of 151049-87-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 151049-87-5 name is 3-Bromo-1-methyl-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
1-methyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrazole A mixture of 3-bromo-1-methyl-1H-pyrazole (100 mg, 0.62 mmol), 1,4-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene (500 mg, 1.52 mmol), K3PO4 (400 mg, 1.88 mmol) and Pd(dtbpf)Cl2 (41 mg, 0.063 mmol) in 1,4-dioxane (2.5 mL) and water (0.5 mL) was stirred at 120 C. for 1 h under microwave irradiation. The mixture was then concentrated in vacuo and the residue purified by Biotage column chromatography (SNAP 25 g column, CH2Cl2/EtOH 100/0->99/1) to give the title compound as a yellow resin (45 mg, 26%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromo-1-methyl-1H-pyrazole, and friends who are interested can also refer to it.
Reference:
Patent; Merck Patent GmbH; Cancer Research Technology, Ltd.; SCHIEMANN, Kai; BLAGG, Julian; MALLINGER, Aurelie; RINK, Christian; SEJBERG, Jimmy; HONEY, Mark; (139 pag.)US2016/16951; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics