Reference of 1226781-82-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1226781-82-3 as follows.
Step (4) The distilled pale yellow wet product IV was dissolved in isopropyl acetate 35kg, and then added dropwise with acid solution at roomtemperature (benzenesulfonic acid 7.7kg and 14kg isopropyl acetate), stirring2d, suction filtration to give a pale gray solid, at 40 deg. C vacuum dried togive a pale gray solid after 10h 7.78kg, 95% yield, purity 98.2%.
According to the analysis of related databases, 1226781-82-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Zhongshan Yian Tai Pharmaceutical Co., Ltd.; Xu, Liang; Mao, Bo; Huang, Zhihong; Li, Yanxiong; (8 pag.)CN105348286; (2016); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics