Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3469-69-0, name is 4-Iodopyrazole, A new synthetic method of this compound is introduced below., Computed Properties of C3H3IN2
(1) Add 19.4 g (0.1 mol) of 4-iodopyrazole, 10.1 g (0.12 mol) of 3,4-dihydro-2H-pyran, and 0.7 g (0.006 mol) of trifluoroacetic acid into the reaction bottle and stir to heat Micro-reflux for 12 hours, the reaction formula of step (1) is as follows:After cooling to room temperature, 0.24 g (0.006 mol) of sodium hydride was added to neutralize the reaction system, and distillation under reduced pressure gave 27.8 g of 4-iodo-1- (tetrahydro-2H-pyran-2-yl) -1H-pyrazole, The product is directly put into the next reaction without purification
The synthetic route of 3469-69-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Changsha Luxing Biological Technology Co., Ltd.; Tan Yongjun; Yang Bing; Zhu Zhiping; Zhang Jianhua; (10 pag.)CN110734401; (2020); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics