Synthetic Route of 155600-99-0,Some common heterocyclic compound, 155600-99-0, name is 3,5-Dibromo-1-methyl-4-nitro-1H-pyrazole, molecular formula is C4H3Br2N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Production example 7 3-bromo-5-(2′-hydroxyethylamino)-1-methyl-4-nitropyrazole 3 g (10.5 mmoles) of 3,5-dibromo-1-methyl-4-nitropyrazole are heated in a solution of 30 ml ethanolamine in 30 ml ethanol for 15 hours at boiling temperature. The reaction mixture is then poured on 200 ml water, the separated product is filtered, washed with water (20 ml) and vacuum dried. Additional product crystallizes from the filtrate when cooled (5 C.). 2.25 g (81 percent of theory) of 3-bromo-5-(2′-hydroxyethyl)amino-1-methyl-4-nitropyrazole are obtained in the form of yellow crystals with a melting point of 150 C. 1 H-NMR (60 MHz, DMSO-d6): =7.38 (s; wide; 1H; –NH; exchangeable with D2 O), 4.98 (s; wide; 1H; –OH; exchangeable with D2 O), 3.82 (s; 3H; N–CH3) and 3.60 ppm (m; 4H; –NH –CH2 –CH2). MS (70 eV):m/e=266 (M+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dibromo-1-methyl-4-nitro-1H-pyrazole, its application will become more common.
Reference:
Patent; Wella Aktiengesellschat; US5663366; (1997); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics