Electric Literature of 1151802-23-1, The chemical industry reduces the impact on the environment during synthesis 1151802-23-1, name is 4-Bromo-1-cyclopropyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.
Bis(pinacolato)diboron (330 mg, 1.3 mmol), NaOAc (262 mg, 3.2 mmol), and Pd(dppf)Cl2-dichloromethane complex (89 mg, O. l lmmol) were combined in a microwave vial. 4-Bromo-l -cyclopropyl- lH-pyrazole and DMF (4 mL) were added and the vial was flushed with argon and sealed. The reaction mixture was heated in a microwave for 60 min at 150 0C. The reaction was diluted with 10 mL water and extracted 3 x 10 mL with EtOAc. The combined organic layers were dried over Na2Stheta4 and concentrated to yield 120 mg of the title compound as a dark oil, m/z 235.4 [M +H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-cyclopropyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; LEMIEUX, Rene, Marc; BRUNETTE, Steven, Richard; HORAN, Joshua, Courtney; KOWALSKI, Jennifer, A.; LAWLOR, Michael, David; MCKIBBEN, Bryan; MILLER, Craig, Andrew; BARBOSA, Antonio, J.M.; WO2010/141273; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics