Application of 10010-93-2, A common heterocyclic compound, 10010-93-2, name is 3-Methyl-5-(trifluoromethyl)-1H-pyrazole, molecular formula is C5H5F3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 128: Preparation of l,5-dimethyl-3-trifluoromethyl-l//-pyrazoleTo a solution of 5-methyl-3-trifluoromethyl-lH-pyrazole (4.13 g, 27.5 mmol) (Example 127) in tetrahydrofuran (60 ml), was added slowly at room temperature potassium tert-butoxide (6.18 g, 55 mmol) and 15 minutes later methyl iodide (3.43 ml, 0 55 mmol). The reaction mixture was stirred for lhour before adding more potassium tert- butoxide (3.09 g, 27.5 mmol). After 30 minutes the reaction mixture was quenched by addition of water and extracted with dichloromethane. The organic extract was dried over magnesium sulfate and concentrated to give l,5-dimethyl-3-trifluoromethyl-lH-pyrazole (3.55 g) which was used in the next step without further purification. 5 1H-NMR (400 MHz, CDCl3): 2.30 (s, 3H, Me)5 3.82 (s, 3H, Me), 6.28 (s, IH, CH) ppm.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SYNGENTA LIMITED; WO2007/71900; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics