Reference of 118430-73-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118430-73-2, name is 3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A solution of 3-tert-butyl-l -methyl- lNo.-pyrazol-5-amine (792 mg), phenyl 3-ethynylphenylcarbamate (Intermediate 13) (1.19 g) and triethylamine (1.4 mL) in THF (30 5 mL) was heated to 60C for 24 hours. Additional triethylamine (0.5 mL) and 3-tert-bu.tyl-l-methyl-lNo.-pyrazol-5-amine (200 mg) were added and the mixture heated for a further 4 hours and concentrated in vacua. The residue was partitioned between DCM and 50% saturated aqueous Na2COs solution. The aquous phase was extracted with DCM and the combined organics washed with 50% saturated aqueous Na2CO3 solution, water and brine and10 concentrated in vacua. Purification by flash chromatography on silica using 0-5% MeOH in DCM as eluent, followed by 20-50% EtOAc in DCM gave the title compound as a white solid (725 mg, 49%)..H NMR (CDC13) 1.30 (s, 9H), 3.08 (s, 1H), 3.75 (s, 3H), 6.11 (s, ), 6.63 (s, 1H), 6.84 (s,1H), 7.19-7.30 (m, 2H), 7.40 (dt, 1H), 7.46 (s, );15 MSm/eMH+297
The synthetic route of 3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/60969; (2005); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics