Sources of common compounds: C7H10N2O2

Statistics shows that 1-Isopropylpyrazole-5-carboxylic Acid is playing an increasingly important role. we look forward to future research findings about 920006-32-2.

Electric Literature of 920006-32-2, These common heterocyclic compound, 920006-32-2, name is 1-Isopropylpyrazole-5-carboxylic Acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 941 -(1 -Methylethyl)-1 H-pyrazole-5-carbonyl chloride Thionyl chloride (5 ml) was added to 1-(1-methylethyl)-1 H-pyrazole-5-carboxylic acid (1g) and the reaction was heated at 800C for 5h. The reaction was evaporated, then azeotroped with toluene to give title compound, 856mg. 1H NMR (CDCI3) delta 7.6 (d, 1 H), delta 7.1 (d, 1 H), delta 5.2 (m, 1 H), delta 1.5 (d, 6H).

Statistics shows that 1-Isopropylpyrazole-5-carboxylic Acid is playing an increasingly important role. we look forward to future research findings about 920006-32-2.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/147188; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics