Electric Literature of 81190-89-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 81190-89-8, name is Methyl 4-bromo-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.
[1197] to a mixture of methyl 4-bromo-1H-pyrazole-3-carboxylate (15.0 g, 73.2 mmol,) andCs2CO3 (59.6 g, 182.9 mmol) in DMF(150 ml) was added mel (14.7 ml, 236.0 mmol) drop-wise at 0c under N2. The mixture was stirred at 25 C for 16 hours. The reaction mixture was filtered, the cake washed with ethyl acetate (200 ml x 2). The filtrate was washed with water (70 ml x 4) and the aqueous phase extracted with ethyl acetate (150 ml). The combined organic extracts were dried over Na2SO4, filtered and concentrated to dryness under reduced pressure to dryness. The crude product which was purified by fcc (gradient eluent: petroleum ether/ethyl acetate from 100/0 to 50/50) to afford the title compound 240a (8.3 g, yield 51.8%) as a white solid and the title compound 240b (7.0 g, yield 43.7%) as white solid. Compound 240a: 1H NMR (400mhz, CDCl3): delta 7.48 (s, 1h), 4.15 (s, 3h), 3.93 (s, 3h). MS (ESI) m/z (M+H)+ 219.0.
The chemical industry reduces the impact on the environment during synthesis Methyl 4-bromo-1H-pyrazole-3-carboxylate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
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