Synthetic Route of 52096-24-9, These common heterocyclic compound, 52096-24-9, name is 1-Butyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3.102 g (18 mmol) of hydrobromic acid was gradually added dropwise to 1.86 g (15 mmol) of 1-butylpyrazole,The reaction was stirred at 40 ~ 50 for 15 ~ 25h to ensure that all the substrates reacted completely, then cyclohexane was used as a water-carrying agent to remove the moisture therein,Further washing with ethyl acetate gave 1-butylpyrazole hydrobromide as a light yellow liquid (yield> 90%).
Statistics shows that 1-Butyl-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 52096-24-9.
Reference:
Patent; Henan University; Ren Tiegang; Wang Tengfei; Ma Yuan; Zhang Jingshun; Zhang Jinglai; Wang Li; (9 pag.)CN107501181; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics