Reference of 5952-93-2, These common heterocyclic compound, 5952-93-2, name is Methyl 1-methyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of LDA (2.0 M in THF) (10.7 mL, 21.42 mmol) in THF (10.0 mL) was added methyl 1-methyl- 1H-pyrazole-4-carboxylate (1.0 g, 7.14 mmol) in THF (10.0 mL) at -78 C slowly and stirred for 2 h. Dimethylformamide (2.5 mL, 32.84 mmol) was added to the reaction mixture at -78C and then allowed to stir at 0 C for 2 h. The reaction mixture was quenched with aqueous 1 M HC1 solution (10 mL) and extracted with EtOAc (3 x 10 mL). The combined organic extracts were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. Crude product was purified with silica gel chromatography using20% EtOAc / petroleum ether to afford 0.200 g of methyl 5-formyl-i-methyl-1H-pyrazole-4- carboxylate as pale yellow solid.?H NMR (400 MHz, CDC13) oe ppm 3.91 (s, 3H), 4.20 (s, 3H), 7.91 (s, 1H), 10.50 (s, 1H).
The synthetic route of 5952-93-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ORION CORPORATION; HAIKARAINEN, Anssi; KUMPULAINEN, Esa; POHJAKALLIO, Antti; PYSTYNEN, Jarmo; WANG, Shouming; (191 pag.)WO2018/2437; (2018); A1;,
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