Application of 25700-12-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25700-12-3 name is 3-(1H-Pyrazol-1-yl)pyridine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a mixture of 3-(1H-pyrazol-1-yl)pyridine (5 g, 34.4 mmol), iodic acid (1.212 g, 6.89 mmol), and iodine (3.50 g, 13.78 mmol) in acetic acid (49.2 ml) was added sulfuric acid (0.918 ml, 17.22 mmol). The reaction mixture heated to 70 C. for 30 min. The reaction mixture was poured onto ice water, extracted with Et2O and then was washed with sodium thiosulfate solution. The organics were then dried with MgSO4, filtered and concentrated in vacuo. The residue purified by flash chromatography eluting with 0-50% acetone in dichloromethane to yielded a light tan solid (6.1 g, 21.38 mmol, 62.1% yield): mp 145-146 C.; 1H NMR (400 MHz, acetone-d6) delta 9.11 (d, J=2.3 Hz, 1H), 8.60 (d, J=0.5 Hz, 1H), 8.56 (dd, J=4.7, 1.4 Hz, 1H), 8.22 (ddd, J=8.3, 2.7, 1.5 Hz, 1H), 7.84 (s, 1H), 7.54 (ddd, J=8.3, 4.7, 0.7 Hz, 1H); EIMS m/z 271.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(1H-Pyrazol-1-yl)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; DOW AGROSCIENCES LLC; Lowe, Christian T.; Trullinger, Tony K.; Hunter, Ricky; US2012/220453; (2012); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics