Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2654-57-1, name is 4-Methyl-1-phenylpyrazolidin-3-one, A new synthetic method of this compound is introduced below., Quality Control of 4-Methyl-1-phenylpyrazolidin-3-one
General procedure: 1a (0.5?mmol), Pd(OAc)2 (5?mol%), AMS (20?mol%), K2CO3 (0.4 equiv.), and dry chlorobenzene (1?mL) were added in a test tube. The reaction mixture was allowed to stir vigorously at 110?C for 6?h. After cooling at room temperature, the mixture was concentrated and the residue was purified by column chromatography on Al2O3 (mobile phase: dichloromethane/methanol or petroleum ether/ethyl acetate) to afford the pure product.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Zhu, Ye-Fu; Wei, Bo-Le; Wei, Jiao-Jiao; Wang, Wen-Qiong; Song, Wei-Bin; Xuan, Li-Jiang; Tetrahedron Letters; vol. 60; 17; (2019); p. 1202 – 1205;,
Pyrazole – Wikipedia,
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