Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1000896-40-1, name is 5-(Benzyloxy)-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows., name: 5-(Benzyloxy)-1H-pyrazol-3-amine
There was dissolved, in ethanol (30 mL), 5-benzyloxy-2H-pyrazol-3-yl-amine (1.52 g, 8.03 mM) and then a methanol solution of sodium methoxide (5.03M, 3.51 mL, 17.7 mM) and diethyl malonate (1.47 mL, 9.64 mM) were added to the solution. This reaction liquid was stirred for 2 hours while refluxing the same with heating. This reaction mixture was filtered and the resulting solid was washed with diethyl ether. After the addition of phosphoryl chloride (10 mL) to the resulting solid with ice-cooling, the resulting suspension was stirred for 3 hours while refluxing the same with heating. The phosphoryl chloride was distilled off from this reaction liquid, ethanol was then added to the residue thus obtained with ice-cooling and the mixture was stirred for 15 minutes. After the concentration of this reaction liquid, the concentrate was purified by the silica gel column chromatography (ethyl acetate/hexane=1:100) to thus give the title compound (167 mg, overall yield of these two steps: 7%). 1H-NMR (300 MHz, CDCl3): delta 5.41 (s, 2H), 6.12 (s, 1H), 6.83 (s, 1H), 7.34-7.40 (m, 3H), 7.48-7.51 (m, 2H); MS (ESI) m/z 294 (M+H)+.
According to the analysis of related databases, 1000896-40-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AJINOMOTO CO., INC.; US2011/294781; (2011); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics