Related Products of 920006-32-2,Some common heterocyclic compound, 920006-32-2, name is 1-Isopropylpyrazole-5-carboxylic Acid, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 2-isopropylpyrazole-3-carboxylic acid (50 mg, 291.89 mumol, 1 eq), 2-methyl-4-[(E)-2-(o-tolyl) vinyl]aniline (93.12 mg, 291.89 mumol, 1 eq), T3P (1.86 g, 2.92 mmol, 1.74 mL, 50%, 10 eq) in pyridine (5 mL) was stirred at 60 C. for 2 h. The mixture was concentrated under reduced pressure to give a residue which was purified by preparative HPLC (column: Phenomenex Gemini 150*25 mm*10 um; mobile phase: [water(0.05% HCl)-ACN]; B %: 55%-85%, 10 min). The mixture was lyophilized, purified by preparative TLC (SiO2, PE/EtOAc=5/1, Rf=0.57) to give 2-isopropyl-N-[2-methyl-4-[(E)-2-(o-tolyl)vinyl]phenyl]pyrazole-3-carboxamide (compound I-42, 18.26 mg, 48.58 mumol, 16.6% yield, 95.6% purity) as an off-white solid. 1H NMR (400 MHz, CDCl3) delta ppm 7.95 (d, J=8.0 Hz, 1H), 7.60-7.55 (m, 3H), 7.40-7.39 (m, 2H), 7.30 (d, J=16.0 Hz, 1H), 7.19-7.17 (m, 3H), 6.96 (d, J=16.0 Hz, 1H), 6.61 (s, 1H), 5.57-5.47 (m, 1H), 2.44 (s, 3H), 2.35 (s, 3H), 1.54 (d, J=6.8 Hz, 6H); ES-LCMS m/z 360.2 [M+H]+.
The synthetic route of 920006-32-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kyn Therapeutics; Castro, Alfredo C.; Evans, Catherine Anne; (108 pag.)US2019/55218; (2019); A1;,
Pyrazole – Wikipedia,
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