Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 73981-23-4, name is Ethyl 3-ethyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., name: Ethyl 3-ethyl-1H-pyrazole-4-carboxylate
Ethyl 5-ethyl-l-(4-methoxybenzyl)-lH-pyrazole-4-carboxylate and ethyl 3-betathyl-l-(4- methoxybenzyl)- 1 H-pyrazole-4-carboxylateAccording to Scheme 9 Step 3: A suspension of ethyl 3-ethyl-lH-pyrazole-4- carboxylate (5.95 mmol, 1.0 g), l-(chloromethyl)-4-methoxybenzene (6.54 mmol, 0.89 mL) and K2CO3 (17.8 mmol, 2.46 g) in acetone (20 mL) was heated at 600C overnight. After evaporation of the solvent, water was added and the aqueous phase was extracted with DCM. The organic phase was dried over Na2SOzI, was filtered and was concentrated under reduced pressure. The crude product was purified by flash chromatography over silica gel using cyclohexane/AcOEt (95:5) as eluent to afford a mixture of ethyl 5-ethyl-l-(4-methoxybenzyl)-lH-pyrazole-4-carboxylate and of ethyl 3-ethyl-l-(4-methoxybenzyl)-lH-pyrazole-4-carboxylate (2.77 mmol, 800 mg, 47%) as a yellow oil.LC (Zorbax SB-Ci8, 3.5mum, 4.6x30mm Column): RT = 2.58 min.
The synthetic route of 73981-23-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Addex Pharma S.A.; WO2009/10455; (2009); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics