At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid, and friends who are interested can also refer to it.
Reference of 796729-03-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 796729-03-8 name is 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step (e) ((ls,4s)-4-(2-(4′-(3-((3S,5R)-3,5-dimethylpiperazin-l-yl)propyl)biphenyl-3- yloxy)-5-fluoronicotinamido)cyclohexyl)-5,6-dihydro-4H-pyrrolo[l,2-b]pyrazole-2- carboxamideTo a suspension of N-((ls,4s)-4-aminocyclohexyl)-2-(4′-(3-((3S,5R)-3,5-dimethylpiperazin-l- yl)propyl)biphenyl-3-yloxy)-5-fluoronicotinamide (150 mg, 0.24 mmol) in acetonitrile (4 mL) was added 5,6-dihydro-4H-pyrrolo[l,2-b]pyrazole-2-carboxylic acid (36.1 mg, 0.24 mmol) and triethylamine (0.330 niL, 2.37 mmol). 1-Propanephosphonic acid cyclic anhydride, 1.57M solution in THF (0.159 mL, 0.25 mmol) was then added and the mixture stirred at RT for 2 hours. The mixture was evaporated to dryness and the residue dissolved in DCM (100 ml) and washed with saturated NaHCO3 (aq), brine, dried (MgSO4) and evaporated to give a foam. This was purified by HPLC to give the title compound as a white solid. Yield: 95 mg1H NMR (400 MHz, CD3OD) delta 8.45 (d, J = 7.4 Hz, IH), 8.12 (d, J = 3.1 Hz, IH), 8.08 – 8.04 (m, IH), 7.52 (d, J = 8.2 Hz, 2H), 7.48 – 7.45 (m, 2H), 7.40 – 7.37 (m, IH), 7.25 (d, J = 8.2 Hz, 2H), 7.17 – 7.11 (m, IH), 6.39 (s, IH), 4.15 – 4.07 (m, IH), 4.04 (t, J = 7.3 Hz, 2H), 3.98 – 3.91 (m, IH), 3.58 – 3.47 (m, 4H), 2.94 – 2.83 (m, 4H), 2.71 (t, J = 7.1 Hz, 2H), 2.64 – 2.52 (m, 4H), 2.06 – 1.93 (m, 2H), 1.89 – 1.76 (m, 6H), 1.74 – 1.63 (m, 2H), 1.33 (d, J = 6.2 Hz, 6H). MS: [M+H]+=694 (calc=694) (MultiMode+)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid, and friends who are interested can also refer to it.