Adding a certain compound to certain chemical reactions, such as: 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1192-21-8, category: pyrazoles-derivatives
General procedure: To a mixture of corresponding 12 (0.14 mmol) and corresponding amine (0.14 mmol) in 1, 4-dioxane (3 mL) was added Pd(OAc)2 (3.00 mg, 0.01 mmol), XantPhos (35.00 mg, 0.06 mmol) and Cs2CO3 (68.00 mg, 0.21 mml). The mixture were heated to 100 oC for 12 h under N2 atmosphere. After completion, the mixture were cooled to room temperature and purification by column chromatography on silica gel to give the corresponding products.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazol-5-amine, and friends who are interested can also refer to it.