Electric Literature of 100114-57-6,Some common heterocyclic compound, 100114-57-6, name is 3-Cyclopropyl-1H-pyrazole, molecular formula is C6H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a cooling (0 C) solution of 3-cyclopropyl-lH-pyrazole (1.5 g, 13.89mmol) in concentrated H2S04 (20 mL, 98%) was added concentrated HNO3 (20 mL, 65%) over 2 min. The reaction mixture was stirred over 1 hr at this temperature. It was then diluted with ice-water and extracted with EA (30 mL X 4). The organic phase was combined and washed with saturated sodium bicarbonate (50 mL). It was dried over Na2S04 and concentrated in vacuo to give a crude product (1.5 g, 70%). This crude product was pure enough to be delivered or used to the next step reaction. MS: [M+H]+ 154. 1H MR (500 MHz, CDC13) delta 0.97 (m, 2H), 1.22(m, 2H), 2.66 (m, 1H), 8.20(s, 1H), 8.38 (s, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Cyclopropyl-1H-pyrazole, its application will become more common.