Application of 152120-54-2, The chemical industry reduces the impact on the environment during synthesis 152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, I believe this compound will play a more active role in future production and life.
To N,N’-di-Boc-1H-pyrazole-1-carboxamidine at 0 C under anhydrous conditions(0.58g, 1.86mmol),tert-Butyl (2S,4S)-4-(((E)-N,N’-bis(tert-butoxycarbonyl)-1H-pyrazole-1-formimido)methyl)-2-((tert-butoxycarbonyl)amino)-7-((tetrahydro-2H-pyran-2-yl)oxy)heptanoate7 (0.8 g, 1.86 mmol) and triphenylphosphine (0.49 g, 1.86 mmol)THF was added dropwise to the solution.Diethyl azodicarboxylate (0.34 mL, 1.86 mmol),After 10 minutes, the reaction was heated at room temperature and stirred overnight.Remove the solvent in vacuo,Purified by flash chromatography (ethyl acetate / hexane 20/80).A colorless oil 6 (1.2 g, 89.1%) was obtained.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, other downstream synthetic routes, hurry up and to see.