Synthetic Route of 10010-93-2, The chemical industry reduces the impact on the environment during synthesis 10010-93-2, name is 3-Methyl-5-(trifluoromethyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.
In a 500 mL round bottom flask, 5-methyl-3-(trifluoromethyl)-1H-pyrazole (150 g,100 mmol), 4-bromo-1-fluoro-2-nitrobenzene (22 g, 100 mmol) and K2C03 (35 g, 250 mmol) were brought up in DMF (200 mL) and the mixture was stirred at 60 C for 6 hrs. The mixture was poured into H20 (200 mL) and extracted with Et20 (100 mL x 3). The combined organic phase was concentrated in vacuo. The crude product was obtained innearly quantitative yield (37 g) and was used for the next reaction without further purification. MS (ESI) 351.1 [M+H]+.
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