In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89501-90-6 as follows. Formula: C4H5ClN2O2S
Methyl 2-(N-isopropyl-1-methyl-1H-pyrazole-3-sulfonamido)acetate. A 25-niL single-neck round-bottomed flask equipped with a magnetic stirrer was charged with 1-methyl-i H-pyrazole-3 – sulfonyl chloride (220 mg, 1.2 mmol), methyl 2-(isopropylamino)-acetate (157 mg, 1.2 mmol), DIPEA (310 mg, 2.4 mmol), DMAP (12 mg, 0.10 mmol), and CH2C12 (10 mL). The mixture was stirred at room temperature for 2 h and concentrated under reduced pressure. The residue was purified by reverse-phase prep-HPLC to afford the title compound (202 mg, 61%) as white solid. MS-ESI:[M+H] 276.1. ?H NMR (500 MHz, CDC13) 3 7.43 (d, J= 2.5 Hz, 1H), 6.74 (d, J= 2.0 Hz, 1H), 4.27-4.24 (m, 1H), 4.02 (s, 2H), 3.99 (s, 3H), 3.77 (s, 3H), 1.09 (d, J= 6.5 Hz, 6H).
According to the analysis of related databases, 89501-90-6, the application of this compound in the production field has become more and more popular.