Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 287922-71-8, name is 4-Bromo-1-methyl-1H-pyrazole-3-carbonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 287922-71-8
Example XXXI -Cvano-1 -methyl-1 /-/-pyrazole-4-carboxylic acid a) 500 mg (2.69 mmol) 4-Bromo-1 -methyl-1 H-pyrazole-3-carbonitrile, 1 .21 mg (5.00 muMuomicronIota) Pd(OAc)2, 44.7 mg (0.08 mmol) dppf and 661 mg (8.06 mmol) NaOAc are added to 20 mL MeOH and stirred in an atmosphere of CO (p = 10 bar) at 120 C over night. Then the solvent is removed and the residue is purified by HPLC (MeOH/H2O/TFA). b) 100 mg (0.61 mmol) of the above mentioned product are added to 16 mL of a 1 /1 mixture of MeOH and THF and charged with 0.23 mL (0.91 mmol) of an aq. NaOH solution (c = 4 mol/L). The resulting mixture is stirred at r.t. over night. Then the solvent is removed, water is added to the residue and the solution is acidified with an aq. HCI solution (c = 1 mol/L). The precipitate is filtered off and dried. C6H5N3O2 (M= 151 .1 g/mol) ESI-MS: 152 [M+H]+ Rt (HPLC): 0.45 min (method D)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.