In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4058-91-7, name is 5-Amino-1-methyl-1H-pyrazole-4-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H7N3O2
As shown in Scheme 1, 3-substituted phenyl-5-methylisoxazole-4-carboxylic acid (0.02mol) was added to distillated SOCl2 (50 mL) and reacted at 80 C for 5 h to obtainintermediate 2. Then, intermediate 2 (0.02 mol) was added dropwise to a stirred solution of5-amino-1-methyl-1H-pyrazole-4-carboxylic acid (0.02 mol) in anhydrous tetrahydrofuran (THF,100 mL) and trimethylamine, the reaction mixture was stirred at room temperature for 2.0 h.The reaction mixture was poured into cold 5.0% dilute HCl solution (200 mL). The solid obtainedwas filtered, washed several times with water, dried to give the crude product which was furtherrecrystallized and dried to give intermediate 3. A mixture of intermediate 3 (0.02 mol) and aceticanhydride (0.2 mol) was heated under reflux for 4.0 h. The solvent was removed under reducedpressure. The residue was washed with water. The separated solid was collected by filtration,washed with water, dried, and recrystallized and dried to give intermediate 4. To a solution ofintermediate 4 (10 mmol) in THF (50 mL), 6 mL of 80% hydrazine hydrate was added slowly atroom temperature. Then, the mixture was further reacted at room temperature for 2 h. The solventwas removed under reduced pressure, and the residue was washed with water and anhydrousethanol to give the crude product, then recrystallized by ethanol and dried under vacuum to give thekey intermediate 3-(2-chlorophenyl)-N-(4-(hydrazinecarbonyl)-1-methyl-1H-pyrazol-5-yl)-5-methylisoxazole-4-carboxamide 5.
The synthetic route of 4058-91-7 has been constantly updated, and we look forward to future research findings.