Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., COA of Formula: C4H3N3O4
4-(2-Thio-5-azabicyclo[2.2.1]heptane-5-ylmethyl)benzene-1,2-diamine (0.7 g, 3 mmol), 4-nitro-1 hydrogen -pyrazole-3-carboxylic acid (0.47 g, 3 mmol)Dissolved in DMF (15 mL) followed by EDCI (0.63 g, 3.3 mmol)HOBt (0.45 g, 3.3 mmol) was stirred at room temperature for 24 hours.The solvent was removed under reduced pressure, and acetic acid (20 mL) was evaporated.After completion of the reaction, concentration and purification by column (dichloromethane/methanol (v/v) = 10/1),The product was obtained (0.5 g, 50percent).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.