These common heterocyclic compound, 175277-11-9, name is 3-tert-Butyl-1-methylpyrazole-5-carboxylic Acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: pyrazoles-derivatives
EXAMPLE 7 N-{5-[(2-aminopyrimidin-5-yl)ethynyl]pyridin-3-yl}-3-tert-butyl-1-methyl-1H-pyrazole-5-carboxamide DIPEA (387 mg) was added to a mixture of 5-[(5-aminopyridin-3-yl)ethynyl]pyrimidin-2-amine (Intermediate 11) (211 mg), 3-tert-butyl-1-methyl-1H-pyrazole-5-carboxylic acid (364 mg) and HBTU (642 mg) in DMF (3 mL) and stirred for 65 hours at ambient temperature. The mixture was added dropwise to stirred 1M aqueous sodium hydroxide (100 mL). The solid formed was filtered off, and purified by RPHPLC to give the title compound (121 mg, 32%); 1H NMR (DMSO-d6) 1.28 (s, 9H), 4.02 (s, 3H), 6.97 (s, 1H), 7.19 (s, 2H) 8.32 (t, 1H), 8.42 (d, 1H), 8.47 (s, 2H), 8.79 (d, 1H) 10.39 (br s, 1H); MS m/e MH+376.
The synthetic route of 3-tert-Butyl-1-methylpyrazole-5-carboxylic Acid has been constantly updated, and we look forward to future research findings.