Adding a certain compound to certain chemical reactions, such as: 35100-92-6, name is 1,5-Dimethyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35100-92-6, category: pyrazoles-derivatives
73 Preparartion of N.N-dicvclopropyl-6-ethyl-l-methyl-4-(l ,5-dimethyl-lH- pyrazol-3-ylamino)-1.6-dihydroimidazo[4.5-dlpyrrolo[2.3-blpyridine-7-carboxamide[00362] To a vial containing 1,5 -dimethyl- lH-pyrazol-3 -amine (13.60 mg, 0.122 mmol), Pd2(dba)3 (4.67 mg, 5.10 muiotaetaomicron), Xantphos (5.90 mg, 10.20 muiotaetaomicron), and cesium carbonate (100 mg, 0.306 mmol) was added N,N-dicyclopropyl-6-ethyl-4-iodo- 1- methyl-l,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide (45.8 mg, 0.102 mmol) in DME (1020 muKappa). The reaction mixture was sparged with argon for 5 min, the vial was capped, and the reaction mixture was heated at 90 C 1 h. The reaction mixture was diluted with dichloromethane and vacuum filtered through Celite. The filtrate was concentrated in vacuo. The crude residue was purified via flash column chromatography using an ISCO 12 g column eluting with 1 – 10%MeOH/CH2Cl2). N,N-Dicyclopropyl-4-(l,5-dimethyl-lH-pyrazol-3-ylamino)-6- ethyl- l-methyl-l,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide (14 mg, 31.7 % yield) was isolated as an off-white solid.[00363] MS (ESI) m/z 433.2 (M+H).[00364] XH NMR (500 MHz, CDC13) delta: 8.19 (s, 1H), 7.63 (s, 1H), 6.94 (s, 1H), 6.85 (s, 1H), 4.65 (q, J = 7.0 Hz, 2H), 3.99 (s, 3H), 3.71 (s, 3H), 2.79 – 2.85 (m, 2H), 2.33 (s, 3H), 1.49 (t, J = 7.2 Hz, 3H), 0.82 – 0.87 (m, 4H), 0.72 – 0.78 (m, 4H)
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