Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25699-98-3, name is 4′-(1-Pyrazolyl)acetophenone, A new synthetic method of this compound is introduced below., name: 4′-(1-Pyrazolyl)acetophenone
General procedure: To a 15 mL dry Schlenk tube with a stirring bar, substrate 1 (0.3 mmol), 2 (0.36 mmol), and [Cp*Co(CO)I2] (5 mol%) were added under air. Then the tube was transferred into the glove box. AgSbF6 (10 mol%) was added. After moving out, DCE(2 mL) was injected into the tube under nitrogen. Then the tube was sealed and the mixture was stirred at 100 C for 12-48 hours. After cooling down, the solvents were removed under reduced pressure and the residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate) to give the desired coupling product.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.