Application of 1203705-55-8, The chemical industry reduces the impact on the environment during synthesis 1203705-55-8, name is 3-Bromo-1H-pyrazol-5-amine, I believe this compound will play a more active role in future production and life.
To a solution of 3-bromo-1H-pyrazol-5-amine (3.2 g, 20.0 mmol) in DMF (60 mL) were added Cs 2CO 3 (13.0 g, 40.0 mmol) and ethyl-3-ethoxyacrylate (8.6 g, 60.0 mmol), the reaction mixture was stirred at 125 C for about 2 h. The reaction mixture was cooled to ambient temperature, poured into H 2O (200 mL), acidified by 1N HCl acid solution, extracted with EA (100 mL 3). The combined organic layers were washed with H 2O (100 mL), concentrated and purified by chromatography on silica gel (eluent: DCM/MeOH = 10/1) to afford the desired compound as a yellow solid (2.0 g). MS (ESI, m/e) [M+1] + 213.9, 214.9.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-1H-pyrazol-5-amine, other downstream synthetic routes, hurry up and to see.