These common heterocyclic compound, 1621-91-6, name is 1H-Pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1H-Pyrazole-3-carboxylic acid
Example 10; Synthesis of (lR)-l-(l-naphthyI)-7V-({l-[4-(trifluoromethyl)phenyl]-lH-pyrazol-3- yl}methyl)ethanamineStep 1. A 500 mL round-bottomed flask was charged with l//-pyrazole-3-carboxylic acid 59 (5.0 g, 45 mmol), 100 mL of MeOH, and 10 drops of concentrated sulfuric acid. This mixture was heated to reflux and heating was continued for 12 h. After cooling to room temperature, the solvent was removed and the residue was dissolved in EtOAc and saturated aqueous NaHCO3. The layers were separated and the organic layer was dried and concentrated to give methyl lH-pyrazole-3-carboxylate 60.
The synthetic route of 1H-Pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.