Synthetic Route of 181585-93-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 181585-93-3 name is Methyl 5-nitro-1H-pyrazole-3-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a stirred solution of methyl 3-nitro-lH-pyrazole-5-carboxylate(A59, 25.0 g, 146.19 mmol) in methanol(500 mL) was added Pd/C(3.80 g, 36.54 mmol) under N2 atmosphere and the reaction mixture was stirred under H2 balloon pressure at room temperature for 4 h. After completion of reaction mixture filtered through celite bed and washed with EtOAc. The filtrate was concentrated to dryness. The residue was washed with n-pentane dried to get methyl 3-amino-lH-pyrazole-5-carboxylate A60 as a pale yellow solid. Yield: 18.0 g(87%) LC-MS(ES) m/z : 142.16[M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 5-nitro-1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.