Application of 1453-58-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 1453-58-3, Name is 3-Methylpyrazole, SMILES is CC1=NNC=C1, belongs to pyrazoles-derivatives compound. In a article, author is Fadda, Ahmed A., introduce new discover of the category.
Synthesis and Anticancer Activity of New 2-Aryl-4-(4-Methoxybenzylidene)-5-Oxazolone Scaffolds
A new series of 4-(4-methoxybenzylidene)-2-substitutedphenyl-5(4H)-oxazolone derivatives has been synthesized through the application of Erlenmeyer condition (Ac2O, AcONa, and 4-anisaldehyde) to the reaction products of the highly versatile p-aminohippuric acid with various electrophilic reagents such as aromatic aldehydes, phenyl isothiocyanate, diazotization-coupling reaction (malononitrile and 2-amino-4-phenylthiazole) and cyanoacetyl-pyrazole. IR, H-1 NMR, and mass spectroscopic techniques were utilized to confirm the structures of these oxazolone scaffolds. The synthesized oxazolone derivatives were evaluated against four human cancer cell lines (HepG2, HTC-116, PC-3, and MCF-7). Compound 3e showed the best activity against hepatocellular carcinoma (IC50 8.9 +/- 0.30 mu g/mL) and colorectal carcinoma (IC50 9.2 +/- 0.63 mu g/mL) cell lines compared with the standard anticancer drug 5-fluorouracil.
Application of 1453-58-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 1453-58-3 is helpful to your research.
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics