Synthetic Route of 330792-70-6, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 330792-70-6, Name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, SMILES is N#CC1=C(N)NN=C1C2=CC=C(OC3=CC=CC=C3)C=C2, belongs to pyrazoles-derivatives compound. In a article, author is Zimnitskiy, Nikolay S., introduce new discover of the category.
An expedient synthesis of novel spiro[indenoquinoxaline-pyrrolizidine]-pyrazole conjugates with anticancer activity from 1,5-diarylpent-4-ene-1,3-diones through the 1,3-dipolar cycloaddition/cyclocondensation sequence
Endo-1,3-Dipolar cycloaddition of azomethine ylides generatedin situfrom 11H-indeno[1,2-b]quinoxalin-11-one andl-proline/thiaproline to (E)-1,5-diarylpent-4-ene-1,3-diones led to the 3-hydroxy-3-aryl-1-(1 ‘-arylspiro[indeno[1,2-b]quinoxaline-11,3 ‘-(thia)pyrrolizidin]-2 ‘-yl)prop-2-en-1-ones containing the 1,3-diketone fragment. Upon processing of these adducts with arylhydrazine hydrochlorides in an acidic medium, the 2 ‘-(1,3-diaryl-1H-pyrazol-5-yl)-1 ‘-arylspiro[indeno[1,2-b]quinoxaline-11,3 ‘-pyrrolizidines] were formed as individual regioisomers. In a similar reaction with hydrazine hydrate and hydroxylamine, the corresponding hybrids bearing theN-unsubstituted pyrazole and isoxazole moieties were obtained. Most of spiro[indenoquinoxaline-pyrrolizidine]-N-arylpyrazole conjugates have shown high cytotoxic activity against the HeLa cancer cell line.
Synthetic Route of 330792-70-6, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 330792-70-6 is helpful to your research.
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics