The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Safety of 4-Phenyl-3H-1,2,4-triazole-3,5(4H)-dione, 4233-33-4, Name is 4-Phenyl-3H-1,2,4-triazole-3,5(4H)-dione, SMILES is O=C1N=NC(=O)N1C1=CC=CC=C1, in an article , author is Zeghada, Sarah, once mentioned of 4233-33-4.
2-Aminobenzaldehyde, a common precursor to acridines and acridones endowed with bioactivities
By starting from a common substrate, 2-aminobenzaldehyde, both acridines and acridones were prepared. The former were generated in high yields by copper-catalyzed N-arylation followed by acid-mediated cyclization while the latter were obtained by double copper-catalyzed N-arylation followed by cyclization under the same reaction conditions. Moreover, acridine was subjected to deprotometalation by recourse to a lithium-zinc base and converted to the corresponding 4-iodo derivative, which was involved in copper-catalyzed couplings with pyrrolidinone and pyrazole. Finally, addition of pyrazole, indole and carbazole onto the 9 position of bare acridine was improved. While moderate biological activity was noticed in melanoma cells growth inhibition, the newly prepared compounds feature interesting photophysical properties which were evaluated in a preliminary study. (C) 2020 Elsevier Ltd. All rights reserved.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 4233-33-4, you can contact me at any time and look forward to more communication. Safety of 4-Phenyl-3H-1,2,4-triazole-3,5(4H)-dione.
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics