Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Akolkar, Hemantkumar N., once mentioned the application of 35344-95-7, Name is 1H-Pyrazole-4-carbaldehyde, molecular formula is C4H4N2O, molecular weight is 96.09, MDL number is MFCD02179514, category is pyrazoles-derivatives. Now introduce a scientific discovery about this category, HPLC of Formula: C4H4N2O.
Design, Synthesis and Biological Evaluation of Novel Furan & Thiophene Containing Pyrazolyl Pyrazolines as Antimalarial Agents
In search for novel compounds targeting Malaria, based on thein silicomolecular docking binding affinity data, the novel furans containing pyrazolyl chalcones (3a-d) and pyrazoline derivatives (4a-d) were synthesized. The formation of the synthesized compound were confirmed by spectral analysis like IR,H-1 NMR,C-13 NMR and mass spectrometry. Compounds with thiophene and pyrazoline ring4b(0.47 mu M),4c(0.47 mu M) and4d(0.21 mu M) exhibited excellent anti-malarial activity againstPlasmodium falciparumcompared with standard antimalarial drug Quinine (0.83 mu M). To check the selectivity furthermore, compounds were tested for antimicrobial activity and none of the synthesized compound exhibited significant potency compared with the standard antibacterial drug Chloramphenicol and antifungal drug Nystatin respectively. So, it can be resolved that the produced compounds show selectively toward antimalarial activity and have the potential to be explored further.
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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics