Chemistry is an experimental science, Recommanded Product: 83-07-8, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 83-07-8, Name is 4-Aminoantipyrine, molecular formula is C11H13N3O, belongs to pyrazoles-derivatives compound. In a document, author is Rao, Mandava Venkata Basaveswara.
In Silico and Biological Evaluation of N-(2-methoxyphenyl) Substituted Pyrazoles Accessed via a Sonochemical Method
In view of remarkable biological properties including anticancer activities of N-aryl pyrazoles we have explored N-(2-methoxyphenyl) substituted pyrazoles and related derivatives as potential cytotoxic agents. In silico methods were adopted to understand/predict the biochemical and physiological effects, toxicity, and biological profiles of these compounds thereby assessing the potential drug-likeness of the hit molecule. The target compounds were conveniently prepared via a sonochemical method involving the C-N bond forming reactions in the presence of CuI in DMSO. A library of N-aryl pyrazole derivatives were synthesized via coupling of iodoarenes with pyrazole whereas the use of other N-heteroarene such as imidazole and pyrrole in place of pyrazole afforded the corresponding product. The in vitro evaluation of all these compounds was carried out against MDAMB-231 and MCF-7 cell lines and subsequently against SIRT1. The pyrazole derivative 3 c showed encouraging growth inhibition of both MDAMB-231 and MCF-7 cell lines (59 and 48 % at 10 mu M, respectively) and inhibition of SIRT1 (IC50 similar to 6.21 +/- 0.42 mu M) in vitro. The molecular docking studies suggested H-bonding (involving OMe group), Van der Waals and hydrophobic interactions of 3 c with important amino acid residues in the catalytic domain of SIRT1. Overall, cell-based as well as enzyme assay, molecular modelling, in silico ADME/TOX prediction and in vitro stability studies suggested 3 c as a potential hit molecule.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 83-07-8. Recommanded Product: 83-07-8.
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics