Interesting scientific research on 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 176969-34-9 help many people in the next few years. Category: pyrazoles-derivatives.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 176969-34-9, Name is 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, formurla is C6H6F2N2O2. In a document, author is da Silva, Michael J., V, introducing its new discovery. Category: pyrazoles-derivatives.

Efficient synthesis and antitumor evaluation of 4-aminomethyl-N-arylpyrazoles: Discovery of potent and selective agents for ovarian cancer

A new one-pot two-step sequential methodology for synthesis of novel 3-carboxyethyl 4-[(tert-butylamino) methyl]-N-arylpyrazole derivatives is reported. One-pot transformation of beta-enamino diketones and arylhydrazines generated 4-iminium-N-arylpyrazole salt intermediates in situ, which were easily transformed into 4[(tert-butylamino)methyl]-N-arylpyrazole derivatives by NaBH3CN. The products could be isolated in the free or hydrochloride salt forms. Also, it was possible to obtain the products in the zwitterionic form by ester group hydrolysis. Furthermore, all synthesised compounds were evaluated in vitro against a panel of eight human tumor cell lines. The 4-[(tert-butylamino)methyl]-N-arylpyrazole derivatives were much more powerful than the hydrochloride and zwitterionic forms. Moreover, the results suggest that the N-aryl group at the pyrazole ring is vital for modulating antiproliferative activity. The 3-carboxyethyl 4-[(tert-butylamino)methyl]-N-phenyl-pyrazoles 3a-g exhibited higher inhibitory activities against OVCAR-3, with GI(50) values of 0.013-8.78 mu M, and lower inhibitory activities against normal human cell lines. Molecular docking was performed to evaluate the probable binding mode of 3a into active site of CDK2.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 176969-34-9 help many people in the next few years. Category: pyrazoles-derivatives.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics