One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 1985-46-2, Name is N2,N2-Dimethyl-1,3,5-triazine-2,4,6-triamine, formurla is C5H10N6. In a document, author is Kumar, K. Subin, introducing its new discovery. Category: pyrazoles-derivatives.
SYNTHESIS, CRYSTAL STRUCTURE, AND IN VITRO CYTOTOXIC, ANTITUMOR AND ANTIMICROBIAL EVALUATION OF A NEW PYRAZOLE DERIVATIVE N-3,5-TRIMETHYL-NPHENYL-1-H-PYRAZOLE-1-CARBOTHIOAMIDE
Anew pyrazole molecule of N-3,5-trimethyl-N-phenyl-1-H-pyrazole-1-carbothioamide (MePhPyC) has been synthesized and characterized by elemental analysis, single crystal x-ray diffraction (XRD), and mass, H-1 NMR, ultraviolet-visible (UV-Vis), and IR spectroscopic techniques. The XRD data show that MePhPyC molecule crystallizes in the monoclinic system, P2(1)/C space group, a = 13.0473(7) angstrom, b = 12.6191(6) angstrom, c = 8.1871(4) angstrom, = 90 degrees, beta = 106.288(2)degrees, v = 90(0) and V =1293.86(11) angstrom(3). The antibacterial activity of MePhPyC against test bacteria and antifungal activity against test fungi were investigated. The compound was found to possess a broad spectrum of biological activities. The synthesized molecule of MePhPyC showed highest cytotoxicity with IC50 = 49 mu g/mL. In the present study, MePhPyC was found to be efficient against EAC-induced ascites tumor. Adose of 5 mg/kg body weight (bwt) was more effective than the other two concentrations (15 and 10 mg/kg bwt). In both cases of in vitro cytotoxicity and in vivo ascites tumor treatment, MePhPyC suggests its potential use as an anticancer agent.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1985-46-2 help many people in the next few years. Category: pyrazoles-derivatives.
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics