Related Products of 143426-52-2,Some common heterocyclic compound, 143426-52-2, name is 1-(4-(Chloromethyl)phenyl)-1H-pyrazole, molecular formula is C10H9ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of 3- ( ( 3R, 4S ) -3-hydroxytetrahydro-2H-pyran-4-yl) -7-methyl-6- (4,4,5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl ) – 2H-benzo [e] [1, 3] oxazin-4 (3H) -one (0.11 g) , l-(4- (chloromethyl) phenyl) -lH-pyrazole (0.06 g) , 2 M aqueous sodium carbonate solution (0.27 mL) and DME (3 mL) was addedtetrakis (triphenylphosphine) palladium (0) (0.02 g) at room temperature, and the mixture was stirred under an argonatmosphere at 90C overnight. The reaction mixture was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) and solidified with ethyl acetate to give the title compound (0.06 g) . NMR (300 MHz, DMSO-d6) delta 1.51-1.70 (1H, m) , 1.75-2.06 (1H, m) , 2.25 (3H, s) , 3.00 (1H, t, J = 10.4 Hz), 3.32-3.40 (1H, m) , 3.66 (1H, tt, J = 10.1, 5.0 Hz), 3.78-3.90 (2H, m) , 4.01 (2H, s), 4.04-4.23 (1H, m) , 5.09 (1H, d, J = 5.7 Hz), 5.18-5.42 (2H, m) , 6.52 (1H, dd, J = 2.5, 1.7 Hz), 6.90 (1H, s) , 7.21-7.27 (2H, m) , 7.57 (1H, s) , 7.70-7.72 (1H, m) , 7.73-7.78 (2H, m) , 8.43 (1H, d, J = 1.9 Hz).
The synthetic route of 143426-52-2 has been constantly updated, and we look forward to future research findings.