Related Products of 133228-21-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 133228-21-4, name is N,N-Dimethyl-1H-pyrazole-1-sulfonamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
19(1) 1-(Dimethylsulfamoyl)-4-fluoropyrazole 2.1 liters of fluorine gas (10% in N2) were bubbled, at 0-5 C., into a solution of 11.1 g of 1-(dimethylsulfamoyl)pyrazole [prepared as described in Example 1(1)] and 25.9 g of sodium acetate in 500 ml of a 9:1 by volume mixture of chloroform and acetic acid. The mixture was stirred for 2 hours, after which it was diluted with water. The organic layer was separated, washed with water and dried over anhydrous sodium sulfate. The solvent was then removed by distillation under reduced pressure. The resulting residue was purified by column chromatography through silica gel, eluted with a 5:1 by volume mixture of hexane and ethyl acetate, to give 1.77 g (yield 14%) of the title compound as an oil.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N,N-Dimethyl-1H-pyrazole-1-sulfonamide, other downstream synthetic routes, hurry up and to see.